InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC25C

Summary

InnateDB Protein

IDBP-377696.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC25C

Protein Name

cell division cycle 25 homolog C (S. pombe)

Synonyms

CDC25; PPP1R60;

Species

Homo sapiens

Ensembl Protein

ENSP00000392631

InnateDB Gene

IDBG-46926 (CDC25C)

Protein Structure

UniProt Annotation

Function

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. {ECO:0000269PubMed:8119945}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14968113, ECO:0000269PubMed:8119945}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	51 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0050699	WW domain binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000087	mitotic M phase
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0007088	regulation of mitosis
GO:0008283	cell proliferation
GO:0016032	viral process
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0051726	regulation of cell cycle