Version 5.4
Homo sapiens Gene: CDC25C
Summary
InnateDB Gene IDBG-46926.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC25C
Gene Name cell division cycle 25 homolog C (S. pombe)
Synonyms CDC25; PPP1R60
Species Homo sapiens
Ensembl Gene ENSG00000158402
Encoded Proteins
IDBP-46928
cell division cycle 25 homolog C (S. pombe)
IDBP-46934
cell division cycle 25 homolog C (S. pombe)
IDBP-377696
cell division cycle 25 homolog C (S. pombe)
IDBP-482328
cell division cycle 25 homolog C (S. pombe)
IDBP-483527
cell division cycle 25 homolog C (S. pombe)
IDBP-475841
cell division cycle 25 homolog C (S. pombe)
IDBP-479312
cell division cycle 25 homolog C (S. pombe)
IDBP-479327
cell division cycle 25 homolog C (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:138285265-138338355
Strand Reverse strand
Band q31.2
Transcripts
ENST00000323760 ENSP00000321656
ENST00000348983 ENSP00000345205
ENST00000415130 ENSP00000392631
ENST00000513970 ENSP00000424795
ENST00000514555 ENSP00000425470
ENST00000514017 ENSP00000423525
ENST00000503022 ENSP00000427251
ENST00000510119 ENSP00000427105
ENST00000504831
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 51 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0050699 WW domain binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000087 mitotic M phase
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006470 protein dephosphorylation
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitosis
GO:0007283 spermatogenesis
GO:0008283 cell proliferation
GO:0016032 viral process
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044201
View Gene Order
ENSBTAG00000005293
Not yet available
Pathways
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_407
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway
REACT_897
G2/M DNA damage checkpoint pathway
REACT_1006
Polo-like kinase mediated events pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_2101
Cyclin B2 mediated events pathway
REACT_828
G2/M Checkpoints pathway
REACT_115566
Cell Cycle pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_1538
Cell Cycle Checkpoints pathway
KEGG
hsa04110
Cell cycle pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
hsa04114
Oocyte meiosis pathway
INOH
PID NCI
plk3_pathway
PLK3 signaling events
atm_pathway
ATM pathway
atr_pathway
ATR signaling pathway
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt P30307
TrEMBL
UniProt Splice Variant
Entrez Gene 995
UniGene Hs.656
RefSeq NM_001287582 NM_001287583 NM_001790 NM_022809 XM_006714740
HUGO HGNC:1727
OMIM 157680
CCDS CCDS4202 CCDS4203
HPRD 01146
IMGT
EMBL AF277723 AF277725 AF277726 AF312681 AJ304504 AY497474 BC019089 CH471062 M34065
GenPept AAA35666 AAG41885 AAG41887 AAG41888 AAH19089 AAL26835 AAR32098 CAC19192 EAW62145 EAW62149
RNA Seq Atlas 995

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca