InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TOP2A

Summary

InnateDB Protein

IDBP-377778.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TOP2A

Protein Name

topoisomerase (DNA) II alpha 170kDa

Synonyms

TOP2; TP2A;

Species

Homo sapiens

Ensembl Protein

ENSP00000411532

InnateDB Gene

IDBG-47552 (TOP2A)

Protein Structure

UniProt Annotation

Function

Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. {ECO:0000269PubMed:22013166, ECO:0000269PubMed:22323612}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22013166}. Nucleus, nucleoplasm {ECO:0000269PubMed:22013166}. Note=Generally located in the nucleoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	81 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0008144	drug binding
GO:0008301	DNA binding, bending
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0000712	resolution of meiotic recombination intermediates
GO:0000819	sister chromatid segregation
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006265	DNA topological change
GO:0006266	DNA ligation
GO:0006268	DNA unwinding involved in DNA replication
GO:0006281	DNA repair
GO:0006312	mitotic recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007059	chromosome segregation
GO:0030261	chromosome condensation
GO:0030263	apoptotic chromosome condensation
GO:0040016	embryonic cleavage
GO:0043065	positive regulation of apoptotic process
GO:0044774	mitotic DNA integrity checkpoint
GO:0045070	positive regulation of viral genome replication
GO:0045870	positive regulation of retroviral genome replication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0000228	nuclear chromosome
GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005814	centriole
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019035	viral integration complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001154 DNA topoisomerase II, eukaryotic-type
IPR001241 DNA topoisomerase, type IIA
IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR012542 DTHCT
IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
IPR013760 DNA topoisomerase, type IIA-like domain
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF00521
PF02518
PF13581
PF08070
PF00204

PRINTS

PR01158
PR00418

PIRSF

SMART

SM00433
SM00434
SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt