InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRU

Summary

InnateDB Protein

IDBP-377921.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRU

Protein Name

protein tyrosine phosphatase, receptor type, U

Synonyms

FMI; hPTP-J; PCP-2; PTP; PTP-J; PTP-PI; PTP-RO; PTPPSI; PTPRO; PTPU2; R-PTP-PSI; R-PTP-U;

Species

Homo sapiens

Ensembl Protein

ENSP00000392332

InnateDB Gene

IDBG-95340 (PTPRU)

Protein Structure

UniProt Annotation

Function

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. {ECO:0000269PubMed:10397721, ECO:0000269PubMed:12501215, ECO:0000269PubMed:16574648}.

Subcellular Localization

Cell junction {ECO:0000269PubMed:8700514}. Cell membrane {ECO:0000269PubMed:8700514}; Single-pass type I membrane protein {ECO:0000269PubMed:8700514}.

Disease Associations

Tissue Specificity

High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells. {ECO:0000269PubMed:8700514, ECO:0000269PubMed:8870675, ECO:0000269PubMed:9070223, ECO:0000269PubMed:9434160}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007155	cell adhesion
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0016311	dephosphorylation
GO:0016337	single organismal cell-cell adhesion
GO:0030154	cell differentiation
GO:0030336	negative regulation of cell migration
GO:0034394	protein localization to cell surface
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0060070	canonical Wnt signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000998 MAM domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00629
PF00041
PF01108

PRINTS

PR00700
PR00020

PIRSF

SMART

SM00194
SM00137
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt