InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCAMP5

Summary

InnateDB Protein

IDBP-377949.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCAMP5

Protein Name

secretory carrier membrane protein 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000406547

InnateDB Gene

IDBG-22989 (SCAMP5)

Protein Structure

UniProt Annotation

Function

Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) in case of endoplasmic reticulum stress by inhibiting the endocytosis pathway. {ECO:0000269PubMed:19234194}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes in Golgi apparatus membrane. Upon calcium- triggered exocytosis, it translocates to the cell membrane. Highly enriched in synaptic vesicles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed both by neuronal and non-neuronal tissues. Expressed in brain, stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and in the different parts of brain. In thyroid tissues, it is expressed by the follicular epithelial cells. In the adrenal gland tissues it is detected in the zona fasciculata of the cortex region (at protein level). {ECO:0000269PubMed:19234194}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006887	exocytosis
GO:0015031	protein transport
GO:0034976	response to endoplasmic reticulum stress
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0050715	positive regulation of cytokine secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031201	SNARE complex
GO:0032588	trans-Golgi network membrane
GO:0055038	recycling endosome membrane