InnateDB Protein
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IDBP-377990.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KIFC3
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Protein Name
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kinesin family member C3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000401696
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InnateDB Gene
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IDBG-33815 (KIFC3)
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Protein Structure
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Function |
Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance. {ECO:0000250, ECO:0000269PubMed:19041755}.
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Subcellular Localization |
Cell junction, adherens junction {ECO:0000269PubMed:19041755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:19041755}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Apical cell membrane. On membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells. Localized in the distal tubules and loops of Henle in the kidney, but not in the proximal tubules or the glomeruli, with stronger staining in the apical area of these epithelial cells (By similarity). Localizes along zonula adherens only at mature cell- cell contacts. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001752
Kinesin, motor domain
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF00225
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PRINTS |
PR00380
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PIRSF |
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SMART |
SM00129
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BVG8
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PhosphoSite |
PhosphoSite-Q9BVG8
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TrEMBL |
H3BTU1
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UniProt Splice Variant |
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Entrez Gene |
3801
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UniGene |
Hs.736934
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RefSeq |
NP_001123572
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HUGO |
HGNC:6326
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OMIM |
604535
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CCDS |
CCDS45493
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HPRD |
05171
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IMGT |
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EMBL |
AB209290
AC010543
AC092118
AF004426
AK291737
BC001211
BC008014
BC034234
BC041132
BC047051
CH471092
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GenPept |
AAC24153
AAH01211
AAH08014
AAH34234
AAH41132
AAH47051
BAD92527
BAF84426
EAW82955
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