Version 5.4
Homo sapiens Gene: KIFC3
Summary
InnateDB Gene IDBG-33815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIFC3
Gene Name kinesin family member C3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000140859
Encoded Proteins
IDBP-33817
kinesin family member C3
IDBP-377990
kinesin family member C3
IDBP-377995
kinesin family member C3
IDBP-751014
IDBP-597169
kinesin family member C3
IDBP-600495
kinesin family member C3
IDBP-599080
kinesin family member C3
IDBP-745149
IDBP-751386
IDBP-752086
IDBP-752759
IDBP-746395
IDBP-748175
IDBP-747996
IDBP-751261
IDBP-752035
IDBP-749377
IDBP-746703
IDBP-752871
IDBP-744927
IDBP-747556
IDBP-747694
IDBP-749662
IDBP-747452
IDBP-748152
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary KIFC3 belongs to the large superfamily of kinesins, molecular motors that use the energy of ATP hydrolysis to translocate cargoes along microtubules. Members share extensive homology within a globular domain containing the microtubule- and ATP-binding sites and have a coiled-coil stalk domain that mediates oligomerization. Different kinesin family members participate in specific and diverse motile processes, such as cell division, organelle transport, and nuclear movement (Hoang et al., 1998 [PubMed 9782090]).[supplied by OMIM, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57758217-57863053
Strand Reverse strand
Band q21
Transcripts
ENST00000379655 ENSP00000368976
ENST00000445690 ENSP00000401696
ENST00000421376 ENSP00000396399
ENST00000465878 ENSP00000454659
ENST00000541240 ENSP00000442008
ENST00000540079 ENSP00000438805
ENST00000543930 ENSP00000444012
ENST00000563028 ENSP00000456354
ENST00000564891 ENSP00000455067
ENST00000569222 ENSP00000457948
ENST00000565351 ENSP00000454632
ENST00000565397 ENSP00000457568
ENST00000565684 ENSP00000455276
ENST00000565753
ENST00000566648 ENSP00000456780
ENST00000561524 ENSP00000454615
ENST00000566914
ENST00000562903 ENSP00000456239
ENST00000562503 ENSP00000454493
ENST00000563295
ENST00000567204
ENST00000569619 ENSP00000456402
ENST00000565481 ENSP00000457326
ENST00000569112 ENSP00000457247
ENST00000566975
ENST00000564204
ENST00000565871
ENST00000564136 ENSP00000458009
ENST00000567479
ENST00000563266
ENST00000562984 ENSP00000454403
ENST00000565270 ENSP00000457232
ENST00000567059 ENSP00000457144
ENST00000562311 ENSP00000454501
ENST00000623271
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007017 microtubule-based process
GO:0007018 microtubule-based movement
GO:0007030 Golgi organization
GO:0007601 visual perception
GO:0008152 metabolic process
GO:0045218 zonula adherens maintenance
GO:0090136 epithelial cell-cell adhesion
Cellular Component
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005915 zonula adherens
GO:0030659 cytoplasmic vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031788
View Gene Order
ENSBTAG00000007181
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.23131 Hs.603754 Hs.681684 Hs.694446 Hs.736934
RefSeq NM_001130099 NM_001130100 NM_005550
HUGO
OMIM
CCDS CCDS10789 CCDS45493 CCDS45494
HPRD 05171
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca