InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAG5

Summary

InnateDB Protein

IDBP-378062.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAG5

Protein Name

BCL2-associated athanogene 5

Synonyms

BAG-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000391713

InnateDB Gene

IDBG-21751 (BAG5)

Protein Structure

UniProt Annotation

Function

Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. {ECO:0000250, ECO:0000269PubMed:20223214}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	43 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031625	ubiquitin protein ligase binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0031397	negative regulation of protein ubiquitination
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0061084	negative regulation of protein refolding
GO:0070997	neuron death
GO:0090083	regulation of inclusion body assembly