Version 5.4
Homo sapiens Gene: BAG5
Summary
InnateDB Gene IDBG-21751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAG5
Gene Name BCL2-associated athanogene 5
Synonyms BAG-5
Species Homo sapiens
Ensembl Gene ENSG00000166170
Encoded Proteins
IDBP-21753
BCL2-associated athanogene 5
IDBP-21755
BCL2-associated athanogene 5
IDBP-378062
BCL2-associated athanogene 5
IDBP-595822
BCL2-associated athanogene 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103556544-103562831
Strand Reverse strand
Band q32.33
Transcripts
ENST00000299204 ENSP00000299204
ENST00000337322 ENSP00000338814
ENST00000445922 ENSP00000391713
ENST00000557666 ENSP00000450497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 43 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0031625 ubiquitin protein ligase binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0031397 negative regulation of protein ubiquitination
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0061084 negative regulation of protein refolding
GO:0070997 neuron death
GO:0090083 regulation of inclusion body assembly
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0016234 inclusion body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049792
View Gene Order
ENSBTAG00000017361
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.5443 Hs.598381 Hs.641715
RefSeq NM_001015048 NM_001015049 NM_004873
HUGO
OMIM
CCDS CCDS41995 CCDS9982
HPRD 04862
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca