InnateDB Protein
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IDBP-378068.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TREML1
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Protein Name
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triggering receptor expressed on myeloid cells-like 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000400405
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InnateDB Gene
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IDBG-86561 (TREML1)
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Protein Structure
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Function |
Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269PubMed:15128762}.
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Subcellular Localization |
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis.
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Disease Associations |
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Tissue Specificity |
Detected in platelets, monocytic leukemia and in T-cell leukemia. {ECO:0000269PubMed:12645956, ECO:0000269PubMed:15100151, ECO:0000269PubMed:15128762, ECO:0000269PubMed:16505478}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86YW5
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PhosphoSite |
PhosphoSite-Q86YW5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
340205
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UniGene |
Hs.117331
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RefSeq |
NP_001258737
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HUGO |
HGNC:20434
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OMIM |
609714
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CCDS |
CCDS64420
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HPRD |
11645
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IMGT |
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EMBL |
AF508193
AF534822
AF534823
AL133404
AY358357
BC100944
BC100945
BC100946
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GenPept |
AAI00945
AAI00946
AAI00947
AAO15020
AAO15021
AAO37827
AAQ88723
CAI19913
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