Version 5.4
Homo sapiens Gene: TREML1
Summary
InnateDB Gene IDBG-86561.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREML1
Gene Name triggering receptor expressed on myeloid cells-like 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161911
Encoded Proteins
IDBP-86563
triggering receptor expressed on myeloid cells-like 1
IDBP-378068
triggering receptor expressed on myeloid cells-like 1
IDBP-378070
triggering receptor expressed on myeloid cells-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41149342-41154337
Strand Reverse strand
Band p21.1
Transcripts
ENST00000373127 ENSP00000362219
ENST00000437044 ENSP00000400405
ENST00000426005 ENSP00000402855
ENST00000590581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0019722 calcium-mediated signaling
GO:0030168 platelet activation
GO:0045087 innate immune response
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0031091 platelet alpha granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023993
View Gene Order
ENSBTAG00000006485
Not yet available
Cross-References
SwissProt Q86YW5
TrEMBL
UniProt Splice Variant
Entrez Gene 340205
UniGene Hs.117331
RefSeq NM_001271807 NM_001271808 NM_178174
HUGO HGNC:20434
OMIM 609714
CCDS CCDS4851 CCDS64420 CCDS64421
HPRD
IMGT
EMBL AF508193 AF534822 AF534823 AL133404 AY358357 BC100944 BC100945 BC100946
GenPept AAI00945 AAI00946 AAI00947 AAO15020 AAO15021 AAO37827 AAQ88723 CAI19913
RNA Seq Atlas 340205

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca