InnateDB Protein
|
IDBP-378117.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
HHIP
|
Protein Name
|
hedgehog interacting protein
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000408587
|
InnateDB Gene
|
IDBG-39723 (HHIP)
|
Protein Structure
|
|
Function |
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269PubMed:11472839, ECO:0000269PubMed:19561609}.
|
Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Secreted {ECO:0000250}. Note=The last 22 C-terminal amino acids may participate in cell membrane attachment.Isoform 2: Cytoplasm {ECO:0000305}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. {ECO:0000269PubMed:11435703, ECO:0000269Ref.1}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0005515
|
protein binding
|
GO:0008270
|
zinc ion binding
|
GO:0016901
|
oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
|
GO:0048038
|
quinone binding
|
GO:0097108
|
hedgehog family protein binding
|
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR018143
Folate receptor-like
|
PFAM |
PF03024
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q96QV1
|
PhosphoSite |
PhosphoSite-Q96QV1
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
64399
|
UniGene |
Hs.729211
|
RefSeq |
|
HUGO |
HGNC:14866
|
OMIM |
606178
|
CCDS |
|
HPRD |
06937
|
IMGT |
|
EMBL |
AC098588
AF326459
AF326460
AF326461
AF326462
AF326463
AF326464
AF326465
AF326466
AF326467
AF326468
AF326469
AF326470
AF326471
AK024645
AK074711
AY009317
AY009951
AY358747
BC009298
BC025311
|
GenPept |
AAG34731
AAG35411
AAH09298
AAH25311
AAK18182
AAQ89107
BAB14945
BAC11154
|
|
|