Version 5.4
Homo sapiens Gene: HHIP
Summary
InnateDB Gene IDBG-39723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HHIP
Gene Name hedgehog interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164161
Encoded Proteins
IDBP-39725
hedgehog interacting protein
IDBP-378117
hedgehog interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:144646021-144745271
Strand Forward strand
Band q31.21
Transcripts
ENST00000296575 ENSP00000296575
ENST00000434550 ENSP00000408587
ENST00000505891
ENST00000511314
ENST00000515080
ENST00000509630
ENST00000512791
ENST00000503090
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0048038 quinone binding
GO:0097108 hedgehog family protein binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007165 signal transduction
GO:0007224 smoothened signaling pathway
GO:0007405 neuroblast proliferation
GO:0009887 organ morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0009968 negative regulation of signal transduction
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048705 skeletal system morphogenesis
GO:0055114 oxidation-reduction process
GO:0060441 epithelial tube branching involved in lung morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064325
View Gene Order
ENSBTAG00000016071
Not yet available
Pathways
NETPATH
NetPath_10
Hedgehog pathway
REACTOME
KEGG
hsa04340
Hedgehog signaling pathway pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Hedgehog signaling pathway pathway
PID NCI
hedgehog_2pathway
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt Q96QV1
TrEMBL
UniProt Splice Variant
Entrez Gene 64399
UniGene Hs.507991 Hs.621002 Hs.670054 Hs.729211
RefSeq NM_022475
HUGO HGNC:14866
OMIM 606178
CCDS CCDS3762
HPRD 06937
IMGT
EMBL AC098588 AF326459 AF326460 AF326461 AF326462 AF326463 AF326464 AF326465 AF326466 AF326467 AF326468 AF326469 AF326470 AF326471 AK024645 AK074711 AY009317 AY009951 AY358747 BC009298 BC025311
GenPept AAG34731 AAG35411 AAH09298 AAH25311 AAK18182 AAQ89107 BAB14945 BAC11154
RNA Seq Atlas 64399

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca