InnateDB Protein
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IDBP-378182.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FBXO22
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Protein Name
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F-box protein 22
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000396442
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InnateDB Gene
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IDBG-23786 (FBXO22)
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Protein Structure
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Function |
Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. {ECO:0000269PubMed:22972877}.
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Subcellular Localization |
Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in liver, also enriched in cardiac muscle. {ECO:0000269PubMed:22972877}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006464
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cellular protein modification process
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GO:0006511
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ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001810
F-box domain
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PFAM |
PF00646
PF12937
PF13013
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PRINTS |
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PIRSF |
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SMART |
SM00256
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NEZ5
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PhosphoSite |
PhosphoSite-Q8NEZ5
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TrEMBL |
H3BUC1
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UniProt Splice Variant |
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Entrez Gene |
26263
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UniGene |
Hs.601357
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RefSeq |
NP_036302
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HUGO |
HGNC:13593
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OMIM |
609096
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CCDS |
CCDS45310
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HPRD |
16437
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IMGT |
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EMBL |
AC027104
AF174602
AK024048
AY005144
BC020204
BC032540
BC039024
BC041691
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GenPept |
AAF04523
AAF89095
AAH20204
AAH32540
AAH39024
AAH41691
BAB14798
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