Version 5.4
Homo sapiens Protein: TAC3
Summary
InnateDB Protein IDBP-378276.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAC3
Protein Name tachykinin 3
Synonyms HH10; NKB; NKNB; PRO1155; ZNEUROK1;
Species Homo sapiens
Ensembl Protein ENSP00000408208
InnateDB Gene IDBG-41810 (TAC3)
Protein Structure
UniProt Annotation
Function Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function. {ECO:0000250, ECO:0000269PubMed:19079066}.
Subcellular Localization Secreted.
Disease Associations Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) [MIM:614839]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic- pituitary axis. In some cases, it is associated with non- reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH). {ECO:0000269PubMed:19079066, ECO:0000269PubMed:23643382}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0007217 tachykinin receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007565 female pregnancy
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003635 Neurokinin-B/Tachykinin-3
PFAM PF03823
PRINTS PR01828
PIRSF PIRSF001843
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHF0
PhosphoSite PhosphoSite-Q9UHF0
TrEMBL Q2UVB8
UniProt Splice Variant
Entrez Gene 6866
UniGene Hs.9730
RefSeq NP_001171525
HUGO HGNC:11521
OMIM 162330
CCDS CCDS53803
HPRD 08877
IMGT
EMBL AF186112 AF216586 AF537113 AF537114 AF537115 AF537116 AF537117 AF537118 AF537119 AF537120 AF537121 AM179832 AY358679 BC032145 CH471054 CR457193
GenPept AAF01430 AAF76980 AAH32145 AAQ10783 AAQ10784 AAQ10785 AAQ10786 AAQ10787 AAQ10788 AAQ10789 AAQ10790 AAQ10791 AAQ89042 CAG33474 CAJ47374 EAW96973 EAW96975 EAW96980

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca