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InnateDB Protein
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IDBP-378453.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FRS3
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Protein Name
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fibroblast growth factor receptor substrate 3
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Synonyms
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FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000396715
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InnateDB Gene
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IDBG-86882 (FRS3)
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Protein Structure
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| Function |
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2. {ECO:0000269PubMed:15094036}.
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| Subcellular Localization |
Membrane; Lipid-anchor.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
6
[view]
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| Protein-Protein |
6
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
3 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0005158
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insulin receptor binding
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR002404
Insulin receptor substrate-1, PTB
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| PFAM |
PF02174
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| PRINTS |
PR00628
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| PIRSF |
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| SMART |
SM00310
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-O43559
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| TrEMBL |
A6PVU0
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| UniProt Splice Variant |
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| Entrez Gene |
10817
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| UniGene |
Hs.194208
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| RefSeq |
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| HUGO |
HGNC:16970
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| OMIM |
607744
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| CCDS |
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| HPRD |
06373
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| IMGT |
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| EMBL |
AL365205
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| GenPept |
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Version 5.4