Version 5.4
Homo sapiens Gene: FRS3
Summary
InnateDB Gene IDBG-86882.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRS3
Gene Name fibroblast growth factor receptor substrate 3
Synonyms FRS2-beta; FRS2B; FRS2beta; SNT-2; SNT2
Species Homo sapiens
Ensembl Gene ENSG00000137218
Encoded Proteins
IDBP-86884
fibroblast growth factor receptor substrate 3
IDBP-86886
fibroblast growth factor receptor substrate 3
IDBP-378453
fibroblast growth factor receptor substrate 3
IDBP-378454
fibroblast growth factor receptor substrate 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. [provided by RefSeq, Jul 2008]
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:41770176-41786542
Strand Reverse strand
Band p21.1
Transcripts
ENST00000373018 ENSP00000362109
ENST00000259748 ENSP00000259748
ENST00000426290 ENSP00000396715
ENST00000422888 ENSP00000413214
ENST00000466420
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0008543 fibroblast growth factor receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023266
View Gene Order
ENSBTAG00000009861
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_111102
Signal Transduction pathway
REACT_116125
Disease pathway
KEGG
INOH
INOH website
FGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.194208
RefSeq NM_006653
HUGO
OMIM
CCDS CCDS4860
HPRD 06373
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca