Version 5.4
Homo sapiens Protein: CISH
Summary
InnateDB Protein IDBP-378595.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CISH
Protein Name cytokine inducible SH2-containing protein
Synonyms BACTS2; CIS; CIS-1; G18; SOCS;
Species Homo sapiens
Ensembl Protein ENSP00000409346
InnateDB Gene IDBG-37175 (CISH)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 29 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 2 [view]
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001496 SOCS protein, C-terminal
PFAM PF00017
PF14633
PF07525
PRINTS PR00401
PIRSF
SMART SM00252
SM00253
SM00969
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NSE2
PhosphoSite PhosphoSite-Q9NSE2
TrEMBL
UniProt Splice Variant
Entrez Gene 1154
UniGene Hs.8257
RefSeq NP_037456
HUGO HGNC:1984
OMIM 602441
CCDS CCDS46834
HPRD 03897
IMGT
EMBL AC096920 AF035947 AF132297 AK313850 BC031590 BC064354 CH471055 D83532
GenPept AAD28471 AAF97410 AAH31590 AAH64354 BAA92328 BAG36578 EAW65128 EAW65129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca