InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP9

Summary

InnateDB Protein

IDBP-378687.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP9

Protein Name

Rho GTPase activating protein 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000397950

InnateDB Gene

IDBG-42628 (ARHGAP9)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269PubMed:11396949}.

Subcellular Localization

Disease Associations

Tissue Specificity

Predominantly expressed in peripheral blood leukocytes, spleen, and thymus. {ECO:0000269PubMed:11396949}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction