InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM2

Summary

InnateDB Protein

IDBP-378759.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM2

Protein Name

tripartite motif containing 2

Synonyms

CMT2R; RNF86;

Species

Homo sapiens

Ensembl Protein

ENSP00000415812

InnateDB Gene

IDBG-41616 (TRIM2)

Protein Structure

UniProt Annotation

Function

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Charcot-Marie-Tooth disease 2R (CMT2R) [MIM:615490]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. {ECO:0000269PubMed:23562820}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0008219	cell death
GO:0016567	protein ubiquitination
GO:0043523	regulation of neuron apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001258 NHL repeat
IPR001298 Filamin/ABP280 repeat
IPR001841 Zinc finger, RING-type
IPR003649 B-box, C-terminal
IPR013017 NHL repeat, subgroup
IPR014756 Immunoglobulin E-set
IPR017868 Filamin/ABP280 repeat-like
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF01436
PF13639
PF14634
PF00630
PF00097

PRINTS

PIRSF

SMART

SM00336
SM00557
SM00184
SM00502

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9C040