Version 5.4
Homo sapiens Gene: TRIM2
Summary
InnateDB Gene IDBG-41616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM2
Gene Name tripartite motif containing 2
Synonyms CMT2R; RNF86
Species Homo sapiens
Ensembl Gene ENSG00000109654
Encoded Proteins
IDBP-41618
tripartite motif containing 2
IDBP-378752
tripartite motif containing 2
IDBP-378759
tripartite motif containing 2
IDBP-378762
tripartite motif containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. Its function has not been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:153152342-153339320
Strand Forward strand
Band q31.3
Transcripts
ENST00000338700 ENSP00000339659
ENST00000441616 ENSP00000400879
ENST00000437508 ENSP00000415812
ENST00000433687 ENSP00000400375
ENST00000491446
ENST00000494872
ENST00000496978
ENST00000479711
ENST00000502281
ENST00000482578
ENST00000460908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0008219 cell death
GO:0016567 protein ubiquitination
GO:0043523 regulation of neuron apoptotic process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027993
View Gene Order
ENSBTAG00000008816
Not yet available
Cross-References
SwissProt Q9C040
TrEMBL C9J084 C9JVI3
UniProt Splice Variant
Entrez Gene 23321
UniGene Hs.435711 Hs.605657 Hs.618741 Hs.667431
RefSeq NM_001130067 NM_015271 XM_006714157 XM_006714158 XM_006714159 XM_006714160 XM_006714161 XM_006714162 XM_006714163 XM_006714164 XM_006714165
HUGO HGNC:15974
OMIM 614141
CCDS CCDS47147 CCDS3781
HPRD 10279
IMGT
EMBL AB011089 AC013477 AC114791 AF220018 AL110234 BC005016 BC011052 CH471056
GenPept AAG53472 AAH05016 AAH11052 BAA25443 CAB53687 EAX04960 EAX04962
RNA Seq Atlas 23321

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca