Version 5.4
Homo sapiens Protein: ADD2
Summary
InnateDB Protein IDBP-378787.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADD2
Protein Name adducin 2 (beta)
Synonyms ADDB;
Species Homo sapiens
Ensembl Protein ENSP00000388072
InnateDB Gene IDBG-55426 (ADD2)
Protein Structure
UniProt Annotation
Function Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. {ECO:0000269PubMed:18347014}.
Subcellular Localization Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Disease Associations
Tissue Specificity Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. {ECO:0000269PubMed:12951058}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0030507 spectrin binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051015 actin filament binding
Biological Process
GO:0006461 protein complex assembly
GO:0030036 actin cytoskeleton organization
GO:0032092 positive regulation of protein binding
GO:0051016 barbed-end actin filament capping
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0008290 F-actin capping protein complex
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID
InterPro IPR001303 Class II aldolase/adducin N-terminal
PFAM PF00596
PRINTS
PIRSF
SMART SM01007
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35612
PhosphoSite PhosphoSite-P35612
TrEMBL C9J299
UniProt Splice Variant
Entrez Gene 119
UniGene Hs.188528
RefSeq NP_059516
HUGO HGNC:244
OMIM 102681
CCDS CCDS46318
HPRD 00037
IMGT
EMBL AB209227 AB593080 AC005234 AC007395 AF486420 AF486421 AF486422 AF486423 AK291007 AK297250 AK309773 BC041666 BC051882 BC056881 BC065525 CH471053 S81077 S81079 U43959 X58199
GenPept AAA86421 AAD12715 AAD14349 AAH41666 AAH51882 AAH56881 AAH65525 AAP71863 AAP71864 AAP71865 AAP71866 BAD92464 BAF83696 BAG59729 BAJ84020 CAA41176 EAW99801 EAW99806 EAW99807 EAW99808

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca