InnateDB Protein
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IDBP-378826.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DCTN2
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Protein Name
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dynactin 2 (p50)
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Synonyms
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DCTN50; DYNAMITIN; HEL-S-77; RBP50;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000408910
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InnateDB Gene
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IDBG-42885 (DCTN2)
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Protein Structure
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Function |
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:8647893}. Membrane {ECO:0000269PubMed:8647893}; Peripheral membrane protein {ECO:0000269PubMed:8647893}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
67
[view]
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Protein-Protein |
67
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q13561
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PhosphoSite |
PhosphoSite-Q13561
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TrEMBL |
V9HW58
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UniProt Splice Variant |
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Entrez Gene |
10540
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UniGene |
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RefSeq |
NP_006391
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HUGO |
HGNC:2712
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OMIM |
607376
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CCDS |
CCDS44930
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HPRD |
09568
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IMGT |
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EMBL |
AC022366
AC022506
AK055682
AK292364
AK314705
AY189155
BC000718
BC009468
BC014083
CH471054
FJ224315
U50733
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GenPept |
AAC50423
AAH00718
AAH09468
AAH14083
AAO34395
ACI46007
BAF85053
BAG37252
BAG51555
EAW97028
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