InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DCTN2

Summary

InnateDB Gene

IDBG-42885.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCTN2

Gene Name

dynactin 2 (p50)

Synonyms

DCTN50; DYNAMITIN; HEL-S-77; RBP50

Species

Homo sapiens

Ensembl Gene

ENSG00000175203

Encoded Proteins

IDBP-378826

dynactin 2 (p50)

IDBP-584617

dynactin 2 (p50)

IDBP-594246

dynactin 2 (p50)

IDBP-590530

dynactin 2 (p50)

IDBP-597184

dynactin 2 (p50)

IDBP-596027

dynactin 2 (p50)

IDBP-603148

dynactin 2 (p50)

IDBP-588867

dynactin 2 (p50)

IDBP-583503

dynactin 2 (p50)

IDBP-583410

dynactin 2 (p50)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:57530102-57547331

Strand

Reverse strand

Band

q13.3

Transcripts

ENST00000434715	ENSP00000408910
ENST00000548249	ENSP00000447824
ENST00000550201	ENSP00000446964
ENST00000549394	ENSP00000447553
ENST00000546758	ENSP00000448937
ENST00000550988
ENST00000552390
ENST00000550086	ENSP00000447308
ENST00000550954	ENSP00000449855
ENST00000551872
ENST00000548736
ENST00000546670	ENSP00000448606
ENST00000551611
ENST00000546965
ENST00000550750	ENSP00000449710
ENST00000548949
ENST00000551142
ENST00000547345
ENST00000551400
ENST00000550576
ENST00000547480
ENST00000546559
ENST00000549712
ENST00000543672	ENSP00000439376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0030507	spectrin binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007017	microtubule-based process
GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032402	melanosome transport

Cellular Component

GO:0000776	kinetochore
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005869	dynactin complex
GO:0005874	microtubule
GO:0016020	membrane
GO:0030286	dynein complex
GO:0030426	growth cone
GO:0031982	vesicle
GO:0070062	extracellular vesicular exosome