InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASGRF1

Summary

InnateDB Protein

IDBP-378876.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRF1

Protein Name

Ras protein-specific guanine nucleotide-releasing factor 1

Synonyms

CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55; PP13187; ras-GRF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000405963

InnateDB Gene

IDBG-25346 (RASGRF1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0035254	glutamate receptor binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007268	synaptic transmission
GO:0007616	long-term memory
GO:0008283	cell proliferation
GO:0031175	neuron projection development
GO:0032320	positive regulation of Ras GTPase activity
GO:0032863	activation of Rac GTPase activity
GO:0035020	regulation of Rac protein signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0046578	regulation of Ras protein signal transduction
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048167	regulation of synaptic plasticity
GO:0048168	regulation of neuronal synaptic plasticity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030426	growth cone
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00612
PF00621
PF00618
PF00169
PF00617

PRINTS

PIRSF

SMART

SM00015
SM00325
SM00229
SM00233
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13972