InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RASGRF1

Summary

InnateDB Gene

IDBG-25346.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRF1

Gene Name

Ras protein-specific guanine nucleotide-releasing factor 1

Synonyms

CDC25; CDC25L; GNRP; GRF1; GRF55; H-GRF55; PP13187; ras-GRF1

Species

Homo sapiens

Ensembl Gene

ENSG00000058335

Encoded Proteins

IDBP-240954

Ras protein-specific guanine nucleotide-releasing factor 1

IDBP-378876

Ras protein-specific guanine nucleotide-releasing factor 1

IDBP-588221

Ras protein-specific guanine nucleotide-releasing factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:78959947-79090773

Strand

Reverse strand

Band

q25.1

Transcripts

ENST00000394745	ENSP00000378228
ENST00000419573	ENSP00000405963
ENST00000558480	ENSP00000452781
ENST00000559926
ENST00000560334
ENST00000560286
ENST00000560943
ENST00000561112
ENST00000623620

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0035254	glutamate receptor binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007268	synaptic transmission
GO:0007616	long-term memory
GO:0008283	cell proliferation
GO:0031175	neuron projection development
GO:0032320	positive regulation of Ras GTPase activity
GO:0032863	activation of Rac GTPase activity
GO:0035020	regulation of Rac protein signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0046578	regulation of Ras protein signal transduction
GO:0046579	positive regulation of Ras protein signal transduction
GO:0048167	regulation of synaptic plasticity
GO:0048168	regulation of neuronal synaptic plasticity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity