InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA5

Summary

InnateDB Protein

IDBP-37896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA5

Protein Name

integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

Synonyms

CD49e; FNRA; VLA5A;

Species

Homo sapiens

Ensembl Protein

ENSP00000293379

InnateDB Gene

IDBG-37894 (ITGA5)

Protein Structure

UniProt Annotation

Function

Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005161	platelet-derived growth factor receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0043184	vascular endothelial growth factor receptor 2 binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001525	angiogenesis
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0007613	memory
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016032	viral process
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589	cell-substrate adhesion
GO:0033631	cell-cell adhesion mediated by integrin
GO:0035313	wound healing, spreading of epidermal cells
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900	leukocyte migration
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0032587	ruffle membrane
GO:0045202	synapse
GO:0071062	alphav-beta3 integrin-vitronectin complex