InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EZH1

Summary

InnateDB Protein

IDBP-379040.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EZH1

Protein Name

enhancer of zeste homolog 1 (Drosophila)

Synonyms

KMT6B;

Species

Homo sapiens

Ensembl Protein

ENSP00000407869

InnateDB Gene

IDBG-51511 (EZH1)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269PubMed:19026781}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19026781}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity