Version 5.4
Homo sapiens Gene: EZH1
Summary
InnateDB Gene IDBG-51511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EZH1
Gene Name enhancer of zeste homolog 1 (Drosophila)
Synonyms KMT6B
Species Homo sapiens
Ensembl Gene ENSG00000108799
Encoded Proteins
IDBP-379039
enhancer of zeste homolog 1 (Drosophila)
IDBP-379040
enhancer of zeste homolog 1 (Drosophila)
IDBP-760645
IDBP-764462
IDBP-760250
IDBP-763985
IDBP-763903
IDBP-763172
IDBP-761499
IDBP-759324
IDBP-758556
IDBP-758784
IDBP-764776
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42700275-42745049
Strand Reverse strand
Band q21.2
Transcripts
ENST00000428826 ENSP00000404658
ENST00000415827 ENSP00000407869
ENST00000587179
ENST00000586103
ENST00000586714
ENST00000586935 ENSP00000465423
ENST00000592492 ENSP00000465482
ENST00000590783
ENST00000585893 ENSP00000467871
ENST00000585912
ENST00000593214 ENSP00000467320
ENST00000588897 ENSP00000467036
ENST00000590078 ENSP00000465220
ENST00000589846
ENST00000585550
ENST00000590082
ENST00000586089 ENSP00000466393
ENST00000592743 ENSP00000466924
ENST00000585455
ENST00000586382 ENSP00000464753
ENST00000588239 ENSP00000468640
ENST00000586867 ENSP00000465327
ENST00000591330
ENST00000593148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046976 histone methyltransferase activity (H3-K27 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
GO:0034968 histone lysine methylation
GO:0070734 histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006920
View Gene Order
ENSBTAG00000021918
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.194669
RefSeq NM_001991 XM_005257144 XM_005257145 XM_005257146
HUGO
OMIM
CCDS CCDS32659
HPRD 03397
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca