InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBBP4

Summary

InnateDB Protein

IDBP-379049.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBBP4

Protein Name

retinoblastoma binding protein 4

Synonyms

lin-53; NURF55; RBAP48;

Species

Homo sapiens

Ensembl Protein

ENSP00000396057

InnateDB Gene

IDBG-95780 (RBBP4)

Protein Structure

UniProt Annotation

Function

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. {ECO:0000269PubMed:10866654}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 216 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	216 [view]
Protein-Protein	214 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0005515	protein binding
GO:0008094	DNA-dependent ATPase activity
GO:0031492	nucleosomal DNA binding
GO:0042393	histone binding
GO:0042826	histone deacetylase binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006334	nucleosome assembly
GO:0006335	DNA replication-dependent nucleosome assembly
GO:0006336	DNA replication-independent nucleosome assembly
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0031497	chromatin assembly
GO:0034080	centromere-specific nucleosome assembly
GO:0043044	ATP-dependent chromatin remodeling
GO:0051726	regulation of cell cycle

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016580	Sin3 complex
GO:0016581	NuRD complex
GO:0016589	NURF complex
GO:0033186	CAF-1 complex
GO:0035098	ESC/E(Z) complex
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR022052 Histone-binding protein RBBP4, N-terminal

PFAM

PF00400
PF12265

PRINTS

PR00320

PIRSF

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt