InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RBM38

Summary

InnateDB Protein

IDBP-379197.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RBM38

Protein Name

RNA binding motif protein 38

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000407848

InnateDB Gene

IDBG-82191 (RBM38)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation. {ECO:0000269PubMed:17050675, ECO:0000269PubMed:19285943}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:17050675}. Nucleus {ECO:0000269PubMed:17050675}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007049	cell cycle
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0008380	RNA splicing
GO:0030154	cell differentiation
GO:0043484	regulation of RNA splicing
GO:0070935	3'-UTR-mediated mRNA stabilization