InnateDB Protein
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IDBP-379210.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDGFC
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Protein Name
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platelet derived growth factor C
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000410048
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InnateDB Gene
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IDBG-42546 (PDGFC)
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Protein Structure
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Function |
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. {ECO:0000269PubMed:10806482, ECO:0000269PubMed:10858496, ECO:0000269PubMed:11297552, ECO:0000269PubMed:11854040, ECO:0000269PubMed:12032822, ECO:0000269PubMed:15061151, ECO:0000269PubMed:15372073, ECO:0000269PubMed:15389578, ECO:0000269PubMed:15728360, ECO:0000269PubMed:15911618, ECO:0000269PubMed:16439802, ECO:0000269PubMed:18055825}.
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Subcellular Localization |
Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Note=Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors.
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Disease Associations |
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Tissue Specificity |
Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes. {ECO:0000269PubMed:10806482, ECO:0000269PubMed:11004490, ECO:0000269PubMed:11297552, ECO:0000269PubMed:11342471, ECO:0000269PubMed:11854040, ECO:0000269PubMed:12176024, ECO:0000269PubMed:15061151, ECO:0000269PubMed:17482170, ECO:0000269PubMed:18055825}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007417
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central nervous system development
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GO:0045740
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positive regulation of DNA replication
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GO:0048008
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platelet-derived growth factor receptor signaling pathway
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GO:0048146
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positive regulation of fibroblast proliferation
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GO:0051781
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positive regulation of cell division
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Cellular Component |
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PDB ID |
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InterPro |
IPR000859
CUB domain
IPR029034
Cystine-knot cytokine
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PFAM |
PF00431
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PRINTS |
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PIRSF |
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SMART |
SM00042
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NRA1
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PhosphoSite |
PhosphoSite-Q9NRA1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56034
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UniGene |
Hs.600482
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RefSeq |
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HUGO |
HGNC:8801
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OMIM |
608452
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CCDS |
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HPRD |
10529
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IMGT |
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EMBL |
AB033831
AC092608
AC093325
AF091434
AF244813
AF260738
AK300480
AM922296
AY358493
BC136662
CH471056
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GenPept |
AAF00049
AAF80597
AAI36663
AAK51637
AAQ88857
AAY40906
BAB03266
BAG62196
CAP58278
EAX04874
EAX04875
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