InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDGFC

Summary

InnateDB Gene

IDBG-42546.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDGFC

Gene Name

platelet derived growth factor C

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000145431

Encoded Proteins

IDBP-42548

platelet derived growth factor C

IDBP-379210

platelet derived growth factor C

IDBP-474152

platelet derived growth factor C

IDBP-477377

platelet derived growth factor C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:156760454-156971394

Strand

Reverse strand

Band

q32.1

Transcripts

ENST00000274071	ENSP00000274071
ENST00000422544	ENSP00000410048
ENST00000502773	ENSP00000422464
ENST00000504672
ENST00000506880	ENSP00000424600
ENST00000510982
ENST00000511985
ENST00000512711
ENST00000513664

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007417	central nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0045740	positive regulation of DNA replication
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048146	positive regulation of fibroblast proliferation
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0051781	positive regulation of cell division
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028019

View Gene Order

ENSBTAG00000043959

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04540

Gap junction pathway

hsa05218

Melanoma pathway

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa05215

Prostate cancer pathway

hsa04510

Focal adhesion pathway

INOH

PID NCI

pdgf_pathway

PDGF receptor signaling network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.566038 Hs.570855 Hs.600482

RefSeq

NM_016205 XM_006714273

HUGO

OMIM

CCDS

CCDS3795

HPRD

10529

IMGT

EMBL

GenPept

RNA Seq Atlas