Version 5.4
Homo sapiens Protein: PHF19
Summary
InnateDB Protein IDBP-379217.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHF19
Protein Name PHD finger protein 19
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000397935
InnateDB Gene IDBG-83105 (PHF19)
Protein Structure
UniProt Annotation
Function Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys- 36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter. {ECO:0000269PubMed:15563832, ECO:0000269PubMed:21143197, ECO:0000269PubMed:23104054, ECO:0000269PubMed:23160351}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15563832}.
Disease Associations
Tissue Specificity Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of cancers, including colon, skin, lung, rectal, cervical, uterus, liver cancers, in cell lines derived from different stages of melanoma and in glioma cell lines. {ECO:0000269PubMed:15563832}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Protein Structure and Domains
PDB ID
InterPro IPR002999 Tudor domain
PFAM PF00567
PRINTS
PIRSF
SMART SM00333
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q5T6S3
TrEMBL X6RER8
UniProt Splice Variant
Entrez Gene 26147
UniGene Hs.460124
RefSeq
HUGO HGNC:24566
OMIM 609740
CCDS
HPRD 17846
IMGT
EMBL AL161911 AL354792
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca