InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NR3C1

Summary

InnateDB Protein

IDBP-379334.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR3C1

Protein Name

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Synonyms

GCCR; GCR; GCRST; GR; GRL;

Species

Homo sapiens

Ensembl Protein

ENSP00000387672

InnateDB Gene

IDBG-51637 (NR3C1)

Protein Structure

UniProt Annotation

Function

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression. {ECO:0000269PubMed:19141540, ECO:0000269PubMed:21664385}.

Subcellular Localization

Cytoplasm. Mitochondrion. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding.Isoform Beta: Nucleus. Note=Localized largely in the nucleus.

Disease Associations

Glucocorticoid resistance (GCRES) [MIM:138040]: Hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant. {ECO:0000269PubMed:11589680, ECO:0000269PubMed:12050230, ECO:0000269PubMed:7683692}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. {ECO:0000269PubMed:10902803}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 227 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	227 [view]
Protein-Protein	201 [view]
Protein-DNA	19 [view]
Protein-RNA	7 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004883	glucocorticoid receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0010467	gene expression
GO:0016568	chromatin modification
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0043402	glucocorticoid mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001409 Glucocorticoid receptor
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF02155
PF00105

PRINTS

PR00528
PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt