Version 5.4
Homo sapiens Protein: PLS3
Summary
InnateDB Protein IDBP-379495.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLS3
Protein Name plastin 3
Synonyms BMND18; T-plastin;
Species Homo sapiens
Ensembl Protein ENSP00000398945
InnateDB Gene IDBG-83039 (PLS3)
Protein Structure
UniProt Annotation
Function Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.
Subcellular Localization Cytoplasm.
Disease Associations Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269PubMed:24088043}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Tissue Specificity Expressed in a variety of organs, including muscle, brain, uterus and esophagus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0060348 bone development
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001715 Calponin homology domain
IPR002048 EF-hand domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
PFAM PF00307
PF00036
PF13202
PF13405
PF11971
PRINTS
PIRSF
SMART SM00033
SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P13797
PhosphoSite PhosphoSite-P13797
TrEMBL F8W8D8
UniProt Splice Variant
Entrez Gene 5358
UniGene Hs.496622
RefSeq
HUGO HGNC:9091
OMIM 300131
CCDS
HPRD 02133
IMGT
EMBL AC003983 AC005000 AK291194 AK294385 AK295429 AK312391 AL589842 BC039049 BC056898 CH471120 L05491 M22299 M34427
GenPept AAA36759 AAA61214 AAB02844 AAH39049 AAH56898 BAF83883 BAG35308 BAG57642 BAG58372 CAI39884 EAX02614

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca