Homo sapiens Gene: PLS3 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-83039.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PLS3 | ||||||||||||||||||||||
Gene Name | plastin 3 | ||||||||||||||||||||||
Synonyms | BMND18; T-plastin | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000102024 | ||||||||||||||||||||||
Encoded Proteins |
plastin 3
plastin 3
plastin 3
plastin 3
plastin 3
plastin 3
plastin 3
plastin 3
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83%% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome X:115561174-115650861 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q23 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | B4DG31 B4DI60 F8W8D8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 5358 | ||||||||||||||||||||||
UniGene | Hs.496622 | ||||||||||||||||||||||
RefSeq | NM_001282337 NM_001136025 NM_001172335 NM_001282338 NM_005032 | ||||||||||||||||||||||
HUGO | HGNC:9091 | ||||||||||||||||||||||
OMIM | 300131 | ||||||||||||||||||||||
CCDS | CCDS14568 CCDS65312 | ||||||||||||||||||||||
HPRD | 02133 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC003983 AC005000 AK294385 AK295429 AL589842 | ||||||||||||||||||||||
GenPept | BAG57642 BAG58372 | ||||||||||||||||||||||
RNA Seq Atlas | 5358 | ||||||||||||||||||||||