InnateDB Protein
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IDBP-379526.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBTF
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Protein Name
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upstream binding transcription factor, RNA polymerase I
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Synonyms
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NOR-90; UBF; UBF-1; UBF1; UBF2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000390669
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InnateDB Gene
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IDBG-53511 (UBTF)
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Protein Structure
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Function |
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. {ECO:0000269PubMed:7982918}.
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Subcellular Localization |
Nucleus, nucleolus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated |
Total |
63
[view]
|
Protein-Protein |
62
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
GO:0006356
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regulation of transcription from RNA polymerase I promoter
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GO:0006360
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transcription from RNA polymerase I promoter
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GO:0006361
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transcription initiation from RNA polymerase I promoter
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GO:0006362
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transcription elongation from RNA polymerase I promoter
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GO:0006363
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termination of RNA polymerase I transcription
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GO:0010467
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gene expression
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GO:0045943
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positive regulation of transcription from RNA polymerase I promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR009071
High mobility group box domain
IPR016024
Armadillo-type fold
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PFAM |
PF00505
PF09011
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PRINTS |
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PIRSF |
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SMART |
SM00398
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TIGRFAMs |
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Modification |
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SwissProt |
P17480
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PhosphoSite |
PhosphoSite-P17480
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TrEMBL |
Q9BQR2
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UniProt Splice Variant |
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Entrez Gene |
7343
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UniGene |
Hs.89781
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RefSeq |
NP_055048
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HUGO |
HGNC:12511
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OMIM |
600673
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CCDS |
CCDS11480
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HPRD |
02814
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IMGT |
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EMBL |
AC004596
AJ308590
AK291733
AK292518
AK296917
BC042297
CH471178
X53390
X53461
X56687
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GenPept |
AAH42297
BAF84422
BAF85207
BAG59472
CAA37469
CAA37548
CAA40016
CAC34632
EAW51616
EAW51617
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