InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBTF

Summary

InnateDB Gene

IDBG-53511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBTF

Gene Name

upstream binding transcription factor, RNA polymerase I

Synonyms

NOR-90; UBF; UBF-1; UBF1; UBF2

Species

Homo sapiens

Ensembl Gene

ENSG00000108312

Encoded Proteins

IDBP-53513

upstream binding transcription factor, RNA polymerase I

IDBP-53515

upstream binding transcription factor, RNA polymerase I

IDBP-243275

upstream binding transcription factor, RNA polymerase I

IDBP-379526

upstream binding transcription factor, RNA polymerase I

IDBP-601132

upstream binding transcription factor, RNA polymerase I

IDBP-588059

upstream binding transcription factor, RNA polymerase I

IDBP-593372

upstream binding transcription factor, RNA polymerase I

IDBP-592837

upstream binding transcription factor, RNA polymerase I

IDBP-602060

upstream binding transcription factor, RNA polymerase I

IDBP-594774

upstream binding transcription factor, RNA polymerase I

IDBP-585439

upstream binding transcription factor, RNA polymerase I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44205033-44221626

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000343638	ENSP00000345297
ENST00000302904	ENSP00000302640
ENST00000393606	ENSP00000377231
ENST00000436088	ENSP00000390669
ENST00000527034	ENSP00000431539
ENST00000533177	ENSP00000437180
ENST00000526094	ENSP00000432925
ENST00000529383	ENSP00000435708
ENST00000529947	ENSP00000433625
ENST00000531368
ENST00000529373	ENSP00000431295
ENST00000529042
ENST00000530828	ENSP00000433046
ENST00000537550

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	62 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000183	chromatin silencing at rDNA
GO:0006356	regulation of transcription from RNA polymerase I promoter
GO:0006360	transcription from RNA polymerase I promoter
GO:0006361	transcription initiation from RNA polymerase I promoter
GO:0006362	transcription elongation from RNA polymerase I promoter
GO:0006363	termination of RNA polymerase I transcription
GO:0010467	gene expression
GO:0045943	positive regulation of transcription from RNA polymerase I promoter