InnateDB Protein
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IDBP-379531.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PBRM1
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Protein Name
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polybromo 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000404579
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InnateDB Gene
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IDBG-39289 (PBRM1)
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Protein Structure
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Function |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation. {ECO:0000269PubMed:21248752}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. {ECO:0000269PubMed:21248752}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:12487023}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
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Protein-Protein |
39
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001487
Bromodomain
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PFAM |
PF00439
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
Q86U86
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PhosphoSite |
PhosphoSite-Q86U86
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TrEMBL |
C9JQF1
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UniProt Splice Variant |
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Entrez Gene |
55193
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UniGene |
Hs.734413
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RefSeq |
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HUGO |
HGNC:30064
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OMIM |
606083
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AC104446
AC112215
AF177387
AF197569
AF225870
AF225871
AF225872
AK056541
AY281068
BC115009
BC115010
BC115011
BC129934
BC129935
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GenPept |
AAG34760
AAG48933
AAG48939
AAG48940
AAG48941
AAI15010
AAI15011
AAI15012
AAI29935
AAI29936
AAP34197
BAB71210
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