InnateDB Protein
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IDBP-379534.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC22A7
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Protein Name
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solute carrier family 22 (organic anion transporter), member 7
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Synonyms
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NLT; OAT2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000393836
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InnateDB Gene
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IDBG-87931 (SLC22A7)
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Protein Structure
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Function |
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate. {ECO:0000269PubMed:11327718, ECO:0000269PubMed:11855680, ECO:0000269PubMed:11907186, ECO:0000269PubMed:12023506, ECO:0000269PubMed:15901346}.
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Subcellular Localization |
Basolateral cell membrane {ECO:0000269PubMed:11907186, ECO:0000269PubMed:12023506}; Multi- pass membrane protein {ECO:0000269PubMed:11907186, ECO:0000269PubMed:12023506}. Note=Apical side of the renal tubule.
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Disease Associations |
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Tissue Specificity |
Expressed in liver and kidney. {ECO:0000269PubMed:11327718, ECO:0000269PubMed:11907186, ECO:0000269PubMed:15901346}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0022857
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transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005828
General substrate transporter
IPR016196
Major facilitator superfamily domain, general substrate transporter
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PFAM |
PF00083
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q9Y694
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TrEMBL |
X6RDF7
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UniProt Splice Variant |
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Entrez Gene |
10864
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UniGene |
Hs.485438
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RefSeq |
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HUGO |
HGNC:10971
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OMIM |
604995
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CCDS |
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HPRD |
05409
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IMGT |
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EMBL |
AL583834
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GenPept |
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