InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: JUND

Summary

InnateDB Protein

IDBP-37956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

JUND

Protein Name

jun D proto-oncogene

Synonyms

AP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000252818

InnateDB Gene

IDBG-37954 (JUND)

Protein Structure

UniProt Annotation

Function

Transcription factor binding AP-1 sites. {ECO:0000269PubMed:9989505}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	68 [view]
Protein-Protein	58 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0002076	osteoblast development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007568	aging
GO:0007623	circadian rhythm
GO:0009416	response to light stimulus
GO:0009612	response to mechanical stimulus
GO:0014070	response to organic cyclic compound
GO:0032496	response to lipopolysaccharide
GO:0043434	response to peptide hormone
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071277	cellular response to calcium ion

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR002112 Transcription factor Jun
IPR004827 Basic-leucine zipper domain
IPR005643 Jun-like transcription factor
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

PFAM

PF00170
PF07716
PF03957

PRINTS

PR00043

PIRSF

SMART

SM00338

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt