InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DUS2L

Summary

InnateDB Protein

IDBP-37965.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DUS2L

Protein Name

dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351769

InnateDB Gene

IDBG-37963 (DUS2L)

Protein Structure

UniProt Annotation

Function

Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. {ECO:0000269PubMed:15994936, ECO:0000269PubMed:18096616}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15994936}. Endoplasmic reticulum {ECO:0000269PubMed:15994936}. Note=Mainly at the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Weak expression in heart, placenta and skeletal muscle. Up-regulated in most lung cancer cells (at protein level). {ECO:0000269PubMed:15994936}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0004860	protein kinase inhibitor activity
GO:0005515	protein binding
GO:0017150	tRNA dihydrouridine synthase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0002943	tRNA dihydrouridine synthesis
GO:0006469	negative regulation of protein kinase activity
GO:0008033	tRNA processing
GO:0055114	oxidation-reduction process
GO:0060548	negative regulation of cell death