Version 5.4
Homo sapiens Gene: DUS2L
Summary
InnateDB Gene IDBG-37963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUS2L
Gene Name dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167264
Encoded Proteins
IDBP-37965
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
IDBP-379505
dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)
IDBP-745479
IDBP-751427
IDBP-754027
IDBP-754712
IDBP-747820
IDBP-751958
IDBP-753024
IDBP-749002
IDBP-749819
IDBP-747344
IDBP-754223
IDBP-754531
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67987746-68079320
Strand Forward strand
Band q22.1
Transcripts
ENST00000358896 ENSP00000351769
ENST00000432752 ENSP00000409498
ENST00000566306 ENSP00000454252
ENST00000562246 ENSP00000463498
ENST00000575677 ENSP00000461659
ENST00000565980
ENST00000569289 ENSP00000456261
ENST00000571081 ENSP00000458906
ENST00000570709 ENSP00000461244
ENST00000564781 ENSP00000456677
ENST00000565263 ENSP00000455229
ENST00000561965 ENSP00000457292
ENST00000576994 ENSP00000458152
ENST00000568099 ENSP00000455977
ENST00000567100 ENSP00000454424
ENST00000564975
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003725 double-stranded RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005515 protein binding
GO:0017150 tRNA dihydrouridine synthase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0002943 tRNA dihydrouridine synthesis
GO:0006469 negative regulation of protein kinase activity
GO:0008033 tRNA processing
GO:0055114 oxidation-reduction process
GO:0060548 negative regulation of cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031901
View Gene Order
ENSBTAG00000014644
Not yet available
Cross-References
SwissProt Q9NX74
TrEMBL A0A024R6Z7 H3BM64 H3BMK6 H3BQX4 H3BRI6 H3BSF3 I3L0K0 I3L1K5 I3L4H0 I3L4Y9 J3QLD5
UniProt Splice Variant
Entrez Gene 54920
UniGene Hs.534460
RefSeq NM_017803 NM_001271762 NM_001271763
HUGO HGNC:26014
OMIM 609707
CCDS CCDS10859 CCDS61970
HPRD 08624
IMGT
EMBL AB101210 AC040162 AC130462 AK000406 AK290578 BC006527 CH471092
GenPept AAH06527 BAA91143 BAE07219 BAF83267 EAW83207 EAW83208 EAW83209
RNA Seq Atlas 54920

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca