|
InnateDB Protein
|
IDBP-379665.5
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
NUP50
|
|
Protein Name
|
nucleoporin 50kDa
|
|
Synonyms
|
NPAP60; NPAP60L;
|
|
Species
|
Homo sapiens
|
|
Ensembl Protein
|
ENSP00000415062
|
|
InnateDB Gene
|
IDBG-11282 (NUP50)
|
|
Protein Structure
|
|
| Function |
Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000269PubMed:20016008}.
|
| Subcellular Localization |
Nucleus, nuclear pore complex {ECO:0000269PubMed:12802065}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase. {ECO:0000250}.
|
| Disease Associations |
|
| Tissue Specificity |
Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
31
[view]
|
| Protein-Protein |
30
[view]
|
| Protein-DNA |
1
[view]
|
| Protein-RNA |
0
|
| DNA-DNA |
0
|
| RNA-RNA |
0
|
| DNA-RNA |
0
|
|
| Predicted by orthology |
| Total |
2 [view]
|
|
|
Molecular Function |
|
| Biological Process |
|
| Cellular Component |
|
| PDB ID |
|
| InterPro |
IPR015007
Nuclear pore complex, NUP2/50/61
|
| PFAM |
PF08911
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
|
| PhosphoSite |
PhosphoSite-Q9UKX7
|
| TrEMBL |
X6RKQ2
|
| UniProt Splice Variant |
|
| Entrez Gene |
10762
|
| UniGene |
Hs.739648
|
| RefSeq |
|
| HUGO |
HGNC:8065
|
| OMIM |
604646
|
| CCDS |
|
| HPRD |
05226
|
| IMGT |
|
| EMBL |
AL008718
Z82243
|
| GenPept |
|
|
|
|
Version 5.4