InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RC3H2

Summary

InnateDB Protein

IDBP-379760.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RC3H2

Protein Name

ring finger and CCCH-type domains 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000411767

InnateDB Gene

IDBG-84229 (RC3H2)

Protein Structure

UniProt Annotation

Function

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS- stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}. Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P- bodies, depends upon the RING-type zinc finger. {ECO:0000269PubMed:20412057}.

Disease Associations

Tissue Specificity

Expressed in spleen, testis, ovary and small intestine. {ECO:0000269PubMed:10938276}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding