Mus musculus Protein: Ddx6
Summary
InnateDB Protein IDBP-379789.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Ddx6
Protein Name Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 (Ddx6), transcript variant 4, mRNA.
Synonyms 1110001P04Rik; C430015D01Rik; E230023J21Rik; HLR2; mRCK/P54; p54; rck;
Species Mus musculus
Ensembl Protein ENSMUSP00000149620
InnateDB Gene IDBG-60130 (Ddx6)
Protein Structure
UniProt Annotation
Function In the process of mRNA degradation, plays a role in mRNA decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573). {ECO:0000250UniProtKB:P26196, ECO:0000269PubMed:26098573}.
Subcellular Localization Cytoplasm, P-body {ECO:0000250UniProtKB:P26196}. Cytoplasm {ECO:0000250UniProtKB:P26196}. Nucleus {ECO:0000250UniProtKB:P26196}. Note=Upon cellular stress, relocalizes to stress granules. {ECO:0000250UniProtKB:P26196}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 98 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0045296 cadherin binding
Biological Process
GO:0006417 regulation of translation
GO:0010501 RNA secondary structure unwinding
GO:0019074 viral RNA genome packaging
GO:0019827 stem cell population maintenance
GO:0033962 cytoplasmic mRNA processing body assembly
GO:0045665 negative regulation of neuron differentiation
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
GO:0016442 RISC complex
GO:0036464 cytoplasmic ribonucleoprotein granule
Protein Structure and Domains
PDB ID MGI:104976
InterPro IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
IPR001650 Helicase, C-terminal
IPR011545 DEAD/DEAH box helicase domain
IPR014001 Helicase superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00271
PF00270
PRINTS
PIRSF
SMART SM00490
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P54823
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 13209
UniGene
RefSeq NP_851841
MGI ID
MGI Symbol Ddx6
OMIM
CCDS CCDS23116
HPRD
IMGT
EMBL AF038995 AK054144 AK148483 BC021452 D50494
GenPept AAB94769 AAH21452 BAA09088 BAC35670 BAE28578