InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEKHG2

Summary

InnateDB Protein

IDBP-379795.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHG2

Protein Name

pleckstrin homology domain containing, family G (with RhoGef domain) member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000392906

InnateDB Gene

IDBG-50331 (PLEKHG2)

Protein Structure

UniProt Annotation

Function

May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein). {ECO:0000250, ECO:0000269PubMed:18045877}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway