InnateDB Protein
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IDBP-380199.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLIN1
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Protein Name
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perilipin 1
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Synonyms
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FPLD4; PERI; PLIN;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402167
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InnateDB Gene
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IDBG-29477 (PLIN1)
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Protein Structure
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Function |
Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269PubMed:23399566}.
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Subcellular Localization |
Endoplasmic reticulum {ECO:0000269PubMed:23399566}. Lipid droplet {ECO:0000269PubMed:23399566}. Note=Lipid droplet surface- associated.
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Disease Associations |
Lipodystrophy, familial partial, 4 (FPLD4) [MIM:613877]: A form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin- resistant diabetes mellitus, hypertriglyceridemia, and hypertension. {ECO:0000269PubMed:21345103}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Adipocytes. {ECO:0000269PubMed:9521880}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004279
Perilipin
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PFAM |
PF03036
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PRINTS |
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PIRSF |
PIRSF036881
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O60240
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PhosphoSite |
PhosphoSite-O60240
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5346
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UniGene |
Hs.712997
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RefSeq |
NP_001138783
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HUGO |
HGNC:9076
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OMIM |
170290
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CCDS |
CCDS10353
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HPRD |
01364
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IMGT |
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EMBL |
AB005293
AC013787
BC031084
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GenPept |
AAH31084
BAA25420
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