Version 5.4
Homo sapiens Protein: DCTN4
Summary
InnateDB Protein IDBP-380263.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DCTN4
Protein Name dynactin 4 (p62)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000414906
InnateDB Gene IDBG-53953 (DCTN4)
Protein Structure
UniProt Annotation
Function Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:10671518}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10671518}. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0047485 protein N-terminus binding
Biological Process
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005869 dynactin complex
Protein Structure and Domains
PDB ID
InterPro IPR008603 Dynactin p62
PFAM PF05502
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UJW0
PhosphoSite PhosphoSite-Q9UJW0
TrEMBL Q9NSJ5
UniProt Splice Variant
Entrez Gene 51164
UniGene Hs.675564
RefSeq NP_001129115
HUGO HGNC:15518
OMIM 614758
CCDS CCDS47310
HPRD 13126
IMGT
EMBL AC008450 AC008453 AF195120 AK000299 AK125973 AL162085 BC026323 CH471062
GenPept AAF03896 AAH26323 BAA91066 BAG54272 CAB82417 EAW61706 EAW61707 EAW61709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca